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doi: 10.3389/fimmu.2025.1604652 Received 02 April 2025 Accepted 23 May 2025 Published 06 June 2025 Volume 16 - 2025 Edited by Zhengyu Jiang, Second Military Medical University, China Reviewed by Feng Zhang, Nanjing University of Chinese Medicine, China Fangyang Fan, Beijing University of Chinese Medicine, China Updates Copyright 2025 Xia, Li, Shi, Sun and He

The development of high-dose GLP-1 receptor agonists and the dual GLP-1/GIP receptor agonist tirzepatide resulted in increasing numbers of people reaching HbA1c and body weight targets, with up to 62% attaining normoglycemia with 15-mg tirzepatide [27]

[198] [201] TAAR1-dependent RhoA signaling has also been shown to internalize EAAT3, a neuronal glutamate transporter expressed in some monoaminergic neurons

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While not a fruit or vegetable in the traditional sense, cacao is a plant-based ingredient rich in polyphenols and magnesium that can support mood and cardiovascular health