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Tests like vitamin B12 levels and blood counts help guide the dosing

Complementing these disease-specific examples, epigenome-wide studies in type 1 diabetes (T1D) have demonstrated methylation abnormalities in immune effector cells (CD4+ T cells, B cells and monocytes), underscoring that immune epigenomes are broadly sensitive to both inflammatory context and metabolic state (112,113)

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Addressing these deficiencies could improve clinical practices and public health strategies, facilitating the incorporation of IF into healthcare recommendations