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What isn't, gets changed

According to FDA-approved prescribing information, gastrointestinal adverse effects occur commonly with these medications, with nausea reported in 16-44% of patients, vomiting in 6-24%, and abdominal pain or distension in 5-18%, depending on the specific medication and dosage

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Reducing BDNF levels by producing conventional BDNF homozygous (/) knockout mice is not practical for this purpose, because such mice do not survive to adulthood 22 and the use of BDNF heterozygous (+/) mice have previously resulted in conflicting findings