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The combination of GLP-1 therapy and renal impairment warrants closer monitoring, though these medications are generally considered safe in moderate kidney disease and some agents have shown potential renal protective benefits in clinical trials

But dose may need adjusting because the slower digestion can change how fast your medication absorbs

Clinical trials of semaglutide for weight loss (STEP program) and tirzepatide (SURMOUNT program) did not report hair loss as a significant adverse event

Liraglutide was the GLP-1RA used in most animal studies (Table 1)

The establishment of workarounds: Even after the shortage ended, compounders were still allowed to customize GLP-1 products for specific patient needs, allowing companies to create slightly altered versions of GLP-1 formulations to prescribe to large numbers of patients