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Chronic mitochondrial ROS production in HF further drives myocyte apoptosis via ROS-mediated activation of caspases and mPTP opening, fibrosis through ROS-activated TGF- signaling in fibroblasts, and electrical instability due to oxidative damage to ion channels, increasing arrhythmia risk

Some patients with HPP may present with seizures

4.3.2 Ethical constraints and study design considerations The inherent ethical constraints preventing randomized controlled trials of EED exposure necessitate reliance on observational study designs

Nutr J 24 , 40 (2025)