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Benign metastasis may explain how 4% of melanoma patients develop metastasized melanomas despite the absence of detectable primary tumors ( Figure 3 Angiogenesis Angiogenesis is a biological process that marks a critical stage in tumor progression where the cells transition from an avascular to a vascular phase, serving as a turning point in melanoma tumor growth and metastasis ( Figure 4 )

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Additionally, LN exhibits distinct pathological grades (IV) with varying immune infiltration and renal damage, but ferroptosis mechanisms across these grades are poorly differentiated

10.3389/fimmu.2018.00978 216 YangT.XiaoH.LiuX.WangZ.ZhangQ.WeiN.et al (2021)