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Pseudomonas is naturally antibiotic resistant on its own, and when it develops a biofilm, it becomes nearly impossible to treat with antibiotics

Thus, EV-associated miRNAs in follicular fluid likely contribute to PCOS pathogenesis by altering granulosa cell functions, though their regulatory mechanisms require further exploration

Romine IC, Wiseman RL (2019) PERK signaling regulates extracellular proteostasis of an amyloidogenic protein during endoplasmic reticulum stress

If the deficiency was purely dietary, oral supplementation may be considered after initial repletion

Questions remain about long-term adherence, weight regain after discontinuation of treatment, and the functional implications of the loss of muscle and bone mass