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Integrating body composition into early trial design Body composition measures should be strategically integrated early in development to maximize their impact on regulatory and commercial positioning

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Similarly, in EGFR-mutant lung cancer, tumor-derived GM-CSF activates PPAR signaling in alveolar macrophages, enhancing cholesterol efflux, which sustains oncogenic EGFR signaling [161]

Prolonged vomiting and reduced fluid intake deplete electrolytes and blood volume, potentially causing low blood pressure, rapid heart rate, and fainting