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Thyroid issues, such as risk of C-cell tumors, have been seen in animal studies (but not yet humans)
Alhasan R, Martins GM, Castro PPde, Saleem RSZ, Zaiter A, Fries I, Kleinclauss A, PerrinSarrado C, Chaimbault P, Jnior ENdaS, Gaucher C, Jacob C (2023) Selenoneine-inspired selenohydantoins with glutathione peroxidase-like activity
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Both of these vitamins are water soluble, so if you are getting an excess of them through your diet or your supplementation, you simply pee it out, which increases the financial value of your urine