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These options include FDA-approved medications for weight management, as well as compounded medications prepared by licensed pharmacies in accordance with a providers prescription

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

So there has been a lot of back and forth on this

This underscores the need for targeted research to refine these guidelines and further research is needed to confirm the optimal g/kg/d protein guidance while on GLP-1RA treatment