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Figure 3 5 The double-edged sword: antiretroviral therapy and mtDNA Antiretroviral therapy (ART) represents one of the most successful medical interventions in modern history, transforming HIV infection from a fatal diagnosis into a manageable chronic condition

(210), it was discovered that CoQ10 supplementation had a positive impact on renal function and reduced kidney O 2 levels in rats that had undergone hemi-nephrectomy, although the effects were not always consistent

Astragaloside IV exhibits pharmacological effects that include anti-inflammatory and antioxidant properties, and enhances the expression of ferroptosis-related proteins GPX4 and SLC7A11, thereby regulating cellular iron transport and mitigating ferroptosis [99]

The neuroprogressive hypothesis has highlighted the importance of oxidative stress and inflammation in schizophrenia, suggesting that these changes may represent possible mechanisms in the progression of the disease (3)