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However, coverage is not entirely ruled out

The activation of GPER has been reported to stimulate the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway [121, 122], resulting in the upregulation of the expression of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx) [123]

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Tirzepatide is FDA-approved (as both Mounjaro and Zepbound), which places it in a more favorable category than unapproved compounds

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