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Since the Apollo-NADP + sensor response depends on the interaction (dimerization) of exogenous mutant G6PD tagged with a fluorescent protein, interactions between transfected and endogenous G6PD may reduce sensor response

Interestingly, the expression of Beclin-1 downregulates the estrogen signal, which is beneficial to overcoming the resistance to tamoxifen (John et al., 2008)