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The altered autoregulation of blood flow cannot meet the metabolic demand of tissues in ME/CFS, leading to tissue hypoxia and subsequent ischaemia/reperfusion injury with its associated symptoms and signs ( Endothelial damage Endothelial cells are important regulators of the immune system (308)

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In conclusion, the activation of GSTs together with other host genes encoding antioxidative and defense enzymes has been often observed during plant-symbiotic microbe interactions that resulted in enhanced resistance against microbial pathogens

Germline SDHB mutations and familial renal cell carcinoma

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