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Annu Rev Pharmacol Toxicol 43:23360 Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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During the progressive stage of cancer, intracellular GSH rates are upregulated to oppose the considerable ROS, thus protecting cancer cells from apoptosis induced by oxidative stress [27]

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Most people experience their most dramatic losses in the first few months as the medication ramps up and appetite suppression is strongest