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Lysyl oxidase, the copper-dependent enzyme that catalyzes the oxidative deamination of lysine residues in collagen and elastin (a step required for the cross-linking that gives mature collagen and elastin their mechanical properties), requires copper as a cofactor

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Methods Consensus clustering, differential gene expression screening, and intersection analysis were used to identify transcription factors involved in WAD

Fibromyalgia is complex, and for some people, medications only go so far

Purity, dosing, long-term outcomes, and safety are not well established in human trials