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The utilization of plasma-activated solutions (PAS), like water, saline, Ringers lactate, culture medium, and phosphate-buffered saline (PBS), as an important complementary application way to direct plasma treatment, has demonstrated favorable treatment effects and application prospects in sterilization, tumor treatment and skin disease management 23,24,25

Applying it directly to depigmented patches alongside an ongoing PUVA regimen can enhance localised melanocyte stimulation and improve the overall repigmentation response

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Notably, in contrast to 23 (HA08), a structurally very similar epimer (HA09) which differs only with regard to one stereogenic center and exhibiting a 100-fold lower affinity to IRAP did not affect spine morphology, indicating a correlation between the capacity to inhibit IRAP and a positive impact on DSD and spine morphology

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