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Providers may favor combination therapy if a patient tolerates GLP-1 well but requires additional glucose-lowering support without adding injectable medications or increasing GLP-1 dose further

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Finally, two other studies found negative correlations with activation in dlPFC, right caudate, limbic and paralimbic regions (Bogdanov et al., 2020

In the UK, NICE recommends these medications only within specialist weight management services, typically for individuals with specific BMI thresholds and weight-related comorbidities who have not achieved adequate weight loss through diet and exercise alone