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15,226,227 Recent therapeutic approaches focus on aldose reductase inhibitors (ARIs), such as epalrestat and ranirestat, which have shown promise in reducing sorbitol accumulation and ameliorating neuropathic symptoms in clinical trials

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(1991), mitochondria were obtained from fresh kidney cortical tissue by homogenization and differential centrifugation

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This research is supported by grants from the National Science and Technology Council, Taiwan (NSTC 112-2326-B-002-006 and NSTC 1122320-B-002-005)

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They work by mimicking natural hormones that slow digestion and help you feel full faster

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Nausea and appetite suppression are the most common side effects during the first few weeks of treatment

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