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In addition, 2-oxoglutarate may also serve as a transcriptional modulator via activation of 2-oxoglutarate oxygenase, which has several biological roles, including demethylation of histones and nucleic acids, and destabilization of transcriptional factor HIF-1 42

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PMCID: PMC3942754

Gastro-Intestinal Side Effects and Discontinuation Real-world data covering 200,000 patients show 42% reporting at least one gastrointestinal event within three months of therapy initiation, with 15% discontinuation by year one

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