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3 , 4 Indeed, a randomized placebo-controlled phase 2 trial demonstrated that among 320 patients with biopsyconfirmed metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis stage 1 to 3, semaglutide 0.4 mg once daily was associated with a significantly higher percentage of patients who achieved MASH resolution with no worsening of fibrosis compared with placebo (59% vs 17%

doi: 10.1111/j.1365-3164.2006.00551.x

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Similar findings were also published in early 1987 by Holst et al., who confirmed that the condensed version could be found in pig small intestines and that both the natural (isolated from pig intestine) and the synthetic version stimulated a two-fold increase in insulin secretion in isolated pig pancreas