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The MitoCHAC1 nucleotide sequence was designed such that the initiating codon was replaced with the coding sequence for the first 25 amino acids of the ornithine transcarbamylase leader sequence 89 to facilitate targeting of exogenous CHAC1 to the mitochondrial matrix

Its important to understand both the bright side and the risks of this therapy to set realistic expectations

This article discusses the benefits of lutein and zeaxanthin, supplement dosages, safety, and food sources

Authors' contributions PM was responsible for all aspects of the manuscript