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Folate production capacity has been studied in various strains of the yeast Saccharomyces cerevisiae and yeast species isolated from environments such as marine and tropic milieus, including fruits, vegetables, fish, and insects, as well as in some bacteria 103,628

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Similarly, double-heterozygous-mutant worms carrying both the D72G and G247Vfs*6 alleles (modeling the two patients carrying the compound heterozygous variants) showed no embryonic lethality, even under prior starvation (Fig