Although storage time did not significantly influence total GSH level, we did observe a slight decrease in GSH level with increased storage time when the ECA cohort was included
In addition, these metabolic effects do not appear to be related to their diuretic action or intended pharmacological targets, raising concerns about the long-term metabolic impact of specific diuretics, particularly in vulnerable populations, including those with metabolic syndrome
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In addition, GLP-1R agonists have recently shown efficacy in reducing heart disease risk and treating certain chronic kidney diseases which has opened the door to potential new indications and label expansions for this drug class in the future
Consequently, phytoconstituents loaded in nanocarriers hold promise for safe and effective drug delivery of active molecules at the site to produce the desired therapeutic outcomes