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Design: A randomized, double-blind, placebo-controlled 20-week study with 2-year extension (sponsor unblinded at 20 weeks, participants/investigators at 1 year) in 19 European clinical research centers

Specifically, we re-estimated the models after excluding observations with Cooks distance values exceeding the conventional threshold of 4/N

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The SURPASS and SURMOUNT trialswhich led to FDA approval of tirzepatidedocumented systolic blood pressure reductions of 46 mmHg on average, with some patients seeing 10+ mmHg drops