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Visceral fat responds faster: Hormonal shifts and energy timing mean visceral and liver fat often decrease before subcutaneous (pinchable) fat

This is the first trial to demonstrate that a medication can change the clinical trajectory of the disease in patients with HFpEF and obesity, Packer added

More than weight loss, the drug has demonstrated ancillary advantages, including up to an 80% reduction in liver fat and alleviation of chronic knee pain and sleep apnea

Science 348 , 636637 (2015)

Tirzepatide before and after weight loss results demonstrate what these percentages look like in practice, and for people with significant weight to lose, the visual transformations are striking