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Apoptotic pathways can be divided into two categories: extrinsic apoptotic pathways triggered by cell death receptors, and intrinsic apoptotic pathways involving dysfunctional mitochondria [109]

If any of these conditions are not met, the risk to the patient outweighs any potential benefit regardless of the outcome being sought

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Sestrin 2 is a leucine sensor that inhibits mTORC1 signaling [87], providing an interesting link between amino acid sensing, mTOR, and NRF2-KEAP1 pathway

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