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The inflammatory microenvironment reduces the glutamate uptake, inducing accumulation of this excitatory amino acid and excitotoxic neurodegeneration

The American Diabetes Association's Standards of Care recommending GLP-1 receptor agonists as preferred second-line agents after metformin and as first-line in patients with high cardiovascular risk create guideline-driven prescription demand that sustains diabetes application dominance

2003 Dec;2(12):731-40