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Therefore, we emphasize a risk-factor-based escalation model, where comorbidities, treatment response, and functional limitations guide progression through treatment steps

A role for melanin-concentrating hormone in the central regulation of feeding behaviour

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The 7TM domain comprises seven -helices (TM1-TM7) separated by three intracellular loops (ICL1-ICL3) and three extracellular loops (ECL1-ECL3), with an additional intracellular C-terminal domain