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Specifically, the addition of cuprizone (bis-cyclohexanone oxalydihydrazone), to the diet process (66) produces a massive demyelination in different areas of the CNS and particularly in the corpus callosum (67-69)

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There was no improvement in fibrosis and hence results may be explained by weight loss rather than a direct result of semaglutide [100]

109111 At the same time, GLP-1R is present in the cardiovascular system, and activation of GLP-1R can reduce or delay vascular changes that are associated with aging, such as arterial stiffness and hypertension

Furthermore, we showed that mEPs released from tendon cells overloaded with a 9% strain (mEP 9% ) induced macrophage chemotaxis and increased the production of proinflammatory cytokines, including IL-6, CXCL1, and IL-18, from macrophages compared to mEP 0% , mEP 3% , and mEP 6%