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5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD

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At steady state, the amount of energy found in the increased NADH/NAD + ratio is about equal to the energy stored across the inner membrane as voltage and proton concentration (pH) gradients