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[8] Approved-drug labeling as a reference point The FDA-approved label for mecasermin (native IGF-1) provides the closest regulated analog and lists recognized risks of IGF-1 exposure, including hypoglycemia (owing to IGF-1s insulin-like metabolic action), intracranial hypertension, tonsillar/adenoidal hypertrophy, and the requirement for caution regarding neoplasia

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