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In this metabolic pathway, a single carbon unit is transferred from serine or glycine to tetrahydrofolate (THF) producing methylene-THF, which is then utilised directly to synthesise the pyrimidine thymidine

The median DRS score was used as the cutoff, with patients scoring below the median defined as sensitive

Because bacteriostatic water contains preservatives, it is suitable for preparing drugs that need to be reused repeatedly

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