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These findings indicate that carnitine supplementation allows normalization of elevated plasma ammonia concentrations

When under oxidative stress (OS) conditions, Hb is oxidized, it binds to the cytoplasmic domain of membrane protein band 3, triggering the formation of aggregates and the covalent linkage of natural anti-band 3 antibodies that may lead to premature RBC removal by splenic macrophages [1, 9]

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This reduction did not take place when mitochondria were only supplied with NADPH and GSSG, indicating that the IMS does not harbour an NADPHdependent GSSG reductase

M.van StraalenL.et al