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(2019) demonstrated that serum levels of TMAO are positively correlated with the serum levels of total BA in patients with MAFLD by conducting a case-control study, and administration of TMAO impairs liver function and increases hepatic triglyceride accumulation and lipogenesis in a murine model

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Sadek et al (163) demonstrated that GLP-1RAs could activate the bifurcated PI3K/Akt/GSK-3 pathway, which affects cellular function on multiple levels