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The CAROLINA study is the only prospective cardiovascular outcomes study to directly compare major adverse cardiovascular events of a DPP-4 inhibitor (linagliptin) with a SU (glimepiride)

Participants received either Orforglipron (12 mg or 36 mg) or oral semaglutide (7 mg or 14 mg) over 52 weeks

Expert Opinions and Guidelines Professional societies like the American Diabetes Association (ADA) now recommend GLP-1 and dual agonist therapies as frontline options for patients with type 2 diabetes, particularly those with obesity or cardiovascular risk factors

[16:10] Natalie Kitroeff And