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Cell Metabolism , 35(2), 213-230

Implication of intestinal barrier dysfunction in gut dysbiosis and diseases

As with the earlier windows, there is no controlled human evidence establishing what happens at weeks five through eight only divergent anecdote

Such ECM stiffness not only enables survival and motility in cancer cells, but also promotes resistance to standard treatments such as chemotherapy and radiotherapy [100]

Future research should further elucidate the regulatory roles of microbial metabolic networks (e.g., bile acids, SCFAs, and tryptophan metabolites) and leverage multi-omics technologies to refine personalized treatment strategies, thereby distinguishing therapeutic responses across PCOS subtypes and advancing precision medicine in reproductive endocrinology