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Liraglutide (ROR = 0.88, 95% CI = 0.761.03) demonstrated a significantly lower risk of psychiatric AEs compared to the overall GLP-1 RAs (ROR = 1.62, 95% CI = 1.561.69)

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On post hoc analyses, we further evaluated the comparative effectiveness of semaglutide versus dulaglutide in the expanded population to contextualize whether a reduction in the primary endpoint, relative to the comparisons including tirzepatide, was similar or greater