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J Cell Biochem 2000 Sep 18

Recent research has identified several adaptive mechanisms through which red blood cells regulate oxygen delivery, including NO-driven changes in membrane deformability, Cys93-dependent S-nitrosylation, adenosine-mediated stimulation of glycolysis and 2,3-BPG production, and the formation of hypoxic memory via degradation of eENT1 ( Beyond their role in gas exchange, erythrocytes participate in a wide range of metabolic and signaling processes

More than 62 proteins are involved directly in transcription, nucleotide metabolism, (de)phosphorylation, or (de)ubiquitinylation, which are all essential processes for cell cycle progression [50]

This includes activities outside of the gym like heavy housework and outdoor landscaping, and lawn work too

Science 352 , 600604 (2016)