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Treatment with yttrium-90DOTA-[D-Phe1-Tyr3]-octreotide ( 90 Y-DOTATOC) decreased serum calcitonin levels as a primary endpoint, and survival benefits in responders were reported in a phase 2 trial of metastatic MTC [47]

They work through several important mechanisms: They increase insulin release from the pancreas when blood glucose is high They reduce excess glucose release from the liver They slow stomach emptying, helping prevent sharp glucose spikes after meals They increase feelings of fullness, often reducing appetite Because these effects depend on blood glucose levels, GLP-1 medications on their own carry a very low risk of causing low blood sugar (hypoglycaemia)

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Smith really listened to my concerns, spelled out options without pressure to go any particular way, and he was supportive and enthusiastic when I made my decision on the route I wanted to take

So far, two studies have examined the effects on body weight