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Disclosure The authors declare that they have no competing interests in this work

A peculiar fact on neurodegenerative disorders is that they are normally characterized by an increased ROS production (Loef et al., 2011) and the decline of BBB and BCB (Sengillo et al., 2013) and human studies (Skillbck et al., 2017) indicate the vulnerability of the NVU in Alzheimers disease, the most common neurodegenerative disease (Muoio et al., 2014), and both protective and trophic functions of the neural barrier seem to be impaired (Zenaro et al., 2017)

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Without clinical guidance, the risk of under- or over-dosing is high