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First-in-class pan-ERR agonist simultaneously activates ERR, ERR, and ERR isoforms Highest potency at ERR (EC50 98 nM) primary regulator of mitochondrial biogenesis and oxidative metabolism Exercise mimetic classification activates acute aerobic exercise genetic response via DDIT4 induction in preclinical models Increases fast oxidative skeletal muscle fibers (Type IIa) in rodent models published in ACS Chemical Biology (2023) Selective over ER, ER, and several closely related nuclear receptors in laboratory assays Non-toxic profile in preclinical cell-based models noted in Sigma-Aldrich reference documentation Referenced at Sigma-Aldrich, MedChemExpress, Cayman Chemical, and ACS Chemical Biology Batch and lot identifiers on all labeling for full laboratory documentation compliance Research Background SLU-PP-332 was developed at Saint Louis University School of Medicine as part of a program investigating synthetic ERR modulators

With the advance of combination therapy, the combination of targeted IGFs and other technologies for the treatment of tumors has shown advantages, which not only increase the efficacy but also effectively prevent the occurrence of drug resistance

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