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In thalassemia patients, the dysregulation of the glutathione antioxidant system can exacerbate the effects of iron overload

Growing evidence indicates that dietary herbs can modulate gut microbiota composition and generate bioactive metabolites that mitigate inflammation, oxidative stress, and apoptosis following stroke, underscoring a promising gut-mediated mechanism for herbal interventions (Li X

Unknown long-term effects : There is no long-term safety data for either compound used individually in the general population, let alone in combination

Annu Rev Med

L-Glutathione can be depleted under heavy bouts of free radical stress or even simply due to aging, as L-glutathione levels naturally decrease over time