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Weight loss velocity peaked between weeks 12 and 24, and most participants reached a plateau around weeks 44 to 48

Start with weights that feel manageable for 8 to 12 repetitions, then gradually increase resistance as your strength improves

Greater background use of these therapies in contemporary practice may reduce baseline event rates and attenuate the absolute number of preventable events

This comprehensive approach underscores the importance of balancing the undeniable benefits of semaglutide with the need to mitigate adverse effects, including UTIs