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The use of peptide dual agonists of the glucagon receptor (GCGR) and the glucagon-like peptide-1 receptor (GLP-1R) is one of the treatment options being researched and evaluated clinically for diabetes, obesity, and related conditions

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But evolution doesn't mean previous solutions became ineffective

Paulose B et al (2013) A -Glutamyl cyclotransferase protects Arabidopsis plants from Heavy Metal Toxicity by Recycling Glutamate to maintain glutathione homeostasis

It also names groups that should avoid the pairing altogether: people who are pregnant or breastfeeding, those with active malignancy or a history of medullary thyroid cancer, and anyone with severe kidney or liver disease