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Metformin also mimics pharmacologic preconditioning (e.g., sevoflurane) by activating Akt and upregulating anti-apoptotic proteins such as Bcl-xL (Rozier et al., 2021)

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Studies demonstrate that losing 710% of body weight can significantly reduce liver fat, improve inflammation, and even reverse fibrosis in some cases

Another finding from the NIH highlights that Metformin users showed significantly lower B12 levels over time compared to non-users , making regular monitoring important for diabetic patients on long term medication