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4c), a viral marker of replication compartments 81 , but did occasionally stain positive for the viral envelope protein gB, suggesting the capsids were closely apposed to the nuclear envelope or perhaps represented perinuclear enveloped virions (Fig

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372 All these astrocytic changes result in considerable and often irreversible neuronal damage, with about 50% of patients demonstrating persistent neurological manifestations even after liver replacement and normalisation of blood ammonium

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