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However, the absence of human clinical trials means the relevance and safety of these mechanisms in humans remains unestablished

It can specifically address these problems through its metabolic regulation, anti-inflammatory effects, and appetite control, thereby optimizing the patient's recovery state

For an individual person, weighing risks and benefits can be helpful, Azagury said

It means hypothyroidism does not automatically shut the door on a promising treatment, and it also means there are clear ways to use these drugs more safely and intelligently

Similarly, IRE1 dysregulation has been observed in tauopathies, PrD, and HD, highlighting its role in neurotoxicity, whereas ATF6 dysfunction exacerbates protein aggregation and has been linked to FTD and tauopathies