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In some cases, neurosteroids exert genomic effects, at least in part, by activation of intracellular steroid receptors (104)

Several complex I inhibitors have been evaluated clinically and discontinued due to neurotoxicity and adverse side effects (IACS-010759, Tamoxifen, Piericidin A, Phenformin) ( A limitation of this study is the discrepancy between the strong in vitro synergy of the MitoQ + DPI combination and its limited effectiveness in in vivo models of NB

When studied together, the combination is investigated for its potential to generate a more complete and organised healing response than either peptide produces independently

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Retrieved May 6, 2025, from MedIndia