glutathione sickle cell disease Oxidative stress in disease: An overview of erythrocyte redox metabolism and current antioxidant therapeutic strategies Ferroptosis as an emerging target

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380,390,402 Another study has proved that PC cells are vulnerable to high zinc concentrations

However, inhibition of SOD enzymes with 2-metoxyestradiol (2-ME) [159], inhibition of CAT by 3-amino-1,2,4-triazole (3AT), depletion of intracellular glutathione with buthionine sulfoximine (BSO) [160] or mercaptosuccinic acid, and combinations of antioxidant inhibitors have been shown to potentiate the antitumor effect of PDT [161, 162]

As a major intracellular reductant, GSH directly scavenges reactive oxygen species and supports enzymatic antioxidant defense pathways such as glutathione peroxidase